In the search for fluids potentially suitable for low-temperature refrigeration applications, we have turned our attention to systems consisting of natural fluids, nitrous oxide (N2O) and ethane (C2H6) in particular. Isochoric PVTx measurements are reported for nitrous oxide + ethane for both the two-phase and the superheated vapor regions at temperatures ranging from (216 to 358) K and pressures from (494 to 5261) kPa along 11 isochores. The data obtained in the two-phase region were used to derive VLE parameters using a flash method with the Carnahan-Starling-De Santis equation of state (CSD EOS). The dew point was also found for each isochore from the intersection of the P-T sequences. The dew points were then used to derive VLE parameters from CSD EOS. Results from the superheated region were compared with the predicted from the virial EOS and CSD EOS.