The solubility of the vitamin E-related compound alpha-tocopheryl succinate in supercritical carbon dioxide was measured at pressures ranging from (15.0 to 30.0) MPa and temperatures of (40 and 50) degrees C using a simple microsampling type apparatus with a 100.5 mu L sample loop to remove aliquots and collect them in ethanol for off line analysis. alpha-Tocopheryl succinate concentrations in the collected samples were measured using HPLC-MS/MS analysis. The solubility of alpha-tocopheryl succinate in supercritical carbon dioxide ranged from mole fractions of 0.28 x 10(-5) at 15.0 MPa and 50 degrees C to 2.56 x 10(-5) at 30.0 MPa and 50 degrees C.