The solubilities of betulin in methanol, ethanol, 1-propanol, 1-butanol, 1-pentanol, 1-hexanol, methyl formate, ethyl formate, methyl acetate, ethyl acetate, chloroform, dichloromethane, cyclohexane, and acetone were measured at T = (278.2, 288.2, 298.2, and 308.2) K. The solubilities of betulin in selected organic solvents increase with temperature. A three-parameter equation was used to correlate the experimental data. These data of solubility can be used to guide the processes of crystallization in industry.