The concentration of propane dissolved in water in the presence of propane gas hydrates has been measured at temperatures from (274 to 277) K and pressures from (150 to 350) kPa. Solubility measurements in the absence of hydrate were found to be in agreement with literature values, which predict an increase in solubility as temperature is decreased. In the hydrate formation region, the solubility of propane decreased with decreasing temperature. Therefore, hydrate formation reverses the gas-liquid solubility trend. Results also show that pressure does not have a strong influence on solubility in the presence of gas hydrate.