Using a laser monitoring observation technique, the solubility of fluorene in dimethylbenzene, methylbenzene, ethanol, isopropanol, and n-butanol from 278.98 K to 338.35 K was experimentally measured by a synthetic method. The results were correlated with a semiempirical equation and provided an indication of the solution nonidealities on the solubility of the solute, which can be used as a useful model in the production of fluorene.