Excess molar enthalpies of four binary systems for acetophenone + (methanol, + ethanol, + I-propanol, and + 2-propanol) at T = (298.15, 313.15, 328.15, 338.15, and 348.15) K and p = (0.1 and 10.0) MPa were determined by a high-pressure flow-mixing isothermal microcalorimeter. The excess molar enthalpies increased with an increase in the temperature, pressure, and the molecular size of alcohols. The experimental data were correlated by the Redlich-Kister equation and three local composition models (Wilson, NRTL, and UNIQUAC).