Excess molar enthalpies of six binary systems for acetophenone + (1-butanol, + 2-methyl-1-propanol, + I-pentanol, + n-heptane, + cyclohexane, and + water) at T = (298.2, 313.2, 328.2, 338.2, and 348.2) K and p = 101.3 kPa and two binary systems for acetophenone + (n-hexane, and + ethyl acetate) at T = (298.2, 313.2, and 328.2) K and p = 101.3 kPa were determined by a flow-mixing isothermal microcalorimeter. The excess molar enthalpies increase with an increase in the temperature. The experimental data were correlated by the Redlich-Kister equation and two local composition models (NRTL and UNIQUAC).