The solubility of uracil in supercritical carbon dioxide (SC-CO2) was determined with dynamic method at temperatures (308, 318, 328, 338, and 348) K and various pressures in the range of (15 to 40) MPa. The mole fraction solubilities of uracil ranged from (0.769 to 14.98).10(-8). The solvent capacity of SC-CO2 to dissolve uracil increases by increasing the pressure at a constant temperature. The crossover point was observed around a pressure of 15 MPa. Experimental data of the solubility of uracil were correlated by the Chrastil model and the modified Chrastil model. The results indicated that the two models were able to successfully correlate the experimental solid uracil + SC-CO2 solubility data, and the values of average absolute relative deviation (AARD) were 12.8 % and 10.1 %, respectively.