The solubility of L-lysine hydrochloride in dimethyl sulfoxide, methanol, ethanol, water, and glycol between (283 and 323) K was measured using a synthetic method at atmospheric pressure. The solubility of L-lysine hydrochloride in the above solvents increased in the order water > dimethyl sulfoxide > glycol > methanol > ethanol. A laser monitoring observation technique was used to determine the disappearance of the solid phase in it solid + liquid mixture. The experimental solubility data were correlated with all empirical equation.