Vapor-liquid equilibrium (VLE) at 101.3 kPa have been determined for a tertiary system (1,3-dioxolane + 2-propanol + 2,2,4-trimethylpentane) and its Constituent binary systems (1,3-dioxolane + 2-propanol, 1,3-dioxolane + 2,2,4-trimethylpentane, and 2-propanol + 2,2,4-trimethylpentane). Minimum boiling azeotropes were observed for all of the three binary systems. No azeotropic behavior was found for the ternary system. The activity coefficients of liquid mixtures were obtained from a modified Raoult's law and were used to calculate the reduced excess molar Gibbs free energy g(E)/RT Thermodynamic consistency tests were performed for all VLE data. The VLE data of the binary mixtures were correlated using the Wilson, NRTL, and UNIQUAC activity coefficient models. The models with their best-fitted interaction parameters of the binary systems were used to predict the tertiary vapor-liquid equilibrium.