This work presents experimental data of vapor-liquid phase behavior in the binary system of trifluoroethane (HFC-143a) + ethyl fluoride (HFC-161) with a single-phase circulation over the temperature range (253.15 to 303.15) K. The correlated results of the vapor-liquid equilibrium data with the Peng-Robinson (PR) equation of state (EoS), combined with the first Modified Huron-Vidal (MHV1) mixing rule and Wilson model, are presented. It is shown that there is a good agreement between the correlated results and the experimental data. The average and maximum absolute derivations of vapor mole fraction are within 0.0209 and 0.0437, respectively, and the average and maximum relative derivations of pressure are within 1.14% and 2.88%, respectively. In addition, from the correlation results, it is revealed that there is no azeotrope in the binary system, and the system exhibits from slightly negative deviations to slightly positive deviations when the temperature increases.