Densities, rho, and compressibility coefficients, k = (nu(o) - nu)/nu(o), of ethylene glycol (1) + dimethylsulfoxide (2) mixtures were measured over the whole concentration range at pressures of (0.1 to 100) MPa and temperatures of (278.15 to 323.15) K. Excess molar volumes, isothermal compressibility, and thermal isobaric expansivity coefficients as well as thermal pressure coefficients were calculated. It was revealed that concentration dependences of specific volumes, nu, at some state parameters passed a minimum. The shift of minimum position to molar fraction x(2) = 0.5 was observed with increasing pressure and decreasing temperature. The negative excess molar volumes, V(m)(E), indicated a compression of EG (1) DMSO (2) systems when mixing. Composition dependences of isothermal compressibility, KT, and thermal isobaric expansivity coefficients, a, as well as thermal pressure coefficients, beta, were near-linear. Both increasing and decreasing of kappa(T) and beta values were observed with x(2) increase depending on temperature and pressure magnitudes within the range of state parameters investigated.