The composition and the solubilization ability of the microemulsion systems containing mixed surfactants of alkyl polyglucoside (APG) and hexadecyl-trimethyl-ammonium bromide (CTAB) were studied by using the epsilon similar to beta fishlike phase diagram method. Synergistic effect in terms of the composition of the interfacial layer and the solubilization ability was observed in microemulsion systems APG + CTAB + alcohol + alkane + NaCl aqueous solution. In the interfacial layer of the microemulsions the number of surfactant molecules notably decreases, resulting in the significant improvement in the solubilization ability of the system. The effects of the carbon chain length of the alkanes and salinity on the epsilon similar to beta fishlike phase diagrams of APG (CTAB) + alcohol + alkane + NaCl solution microemulsion systems were also discussed.