The present work describes the synthesis of new 5,11,17,23-tetrakis[(propylthio)methyl]-25,26,27,28-tetrahydroxycalix[4]arene (3) based impregnated resin, its characterization, and sorption behavior for the removal of endosulfan from water. The impregnated resin was characterized through various analytical techniques such as Fourier transform infrared (FT-IR) spectroscopy, scanning electron microscopy (SEM), and gravimetric analysis. The sorption efficiency of resin was checked through batch as well as column experiments. Different parameters such as pH, contact time, sorbent dosage, and temperature for the sorption of endosulfan were optimized as 2,60 min, 3 mg, and 293 K, respectively. Freundlich and Langmuir sorption isotherms were applied to the data to validate the sorption process. The Thomas model was used to calculate the kinetic coefficient (k(TH)) and maximum sorption capacity (q(o)) of the resin, which were (3.40 and 3.46) mL . mg(-1) . min(-1) as well as (0.338 and 0.318) mg . g(-1) for alpha- and beta-endosulfan, respectively. Besides this, Lagergren and Morris-Weber equations for kinetic studies show that sorption follows the pseudofirst-order rate equation. The developed sorption method has been applied to polluted surface water samples with a percent removal of 99.5 +/- 1 % for both endosulfan isomers.