The solubility data of azadirachtin in supercritical carbon dioxide were measured at several temperatures (308.15, 313.15, 318.15, 323.15, 328.15, and 333.15 K) and at pressure between (10 and 26) MPa. The measurement of solubility data was conducted in static mode. The experimental results were correlated by Chrastil model and Del valle and Aguilera equation. Chrastil model can represent the experimental data well and give a reasonable value for fitting parameters.