Isothermal vapor-liquid equilibrium (VLE) data (P-T-x-y) were measured and modeled for the propan-1-ol + dodecane system at (323.0, 343.4, 353.2, 363.1, and 369.2) K. The VLE data were measured using a dynamic-analytic method. The equilibrium cell used is a modified ebulliometer which allows for recirculation of both the liquid and the vapor phases and is capable of measuring systems of high relative volatility. The sampled equilibrium phases were analyzed and quantified using a gas chromatograph with a thermal conductivity detector. The measured experimental data were modeled using the gamma-phi approach with the nonrandom two-liquid (NRTL) activity coefficient model to account for the liquid phase nonideality and the vapor phase assumed to be ideal. Fitting of the activity coefficient model was undertaken by nonlinear least-squares regression of the experimental data. Thermodynamic consistency testing of the experimental data was undertaken with the Van Ness test, with the data successfully passing the test.