The solubility of 19 halogenated alkanes was measured in polar and nonpolar organic solvents using a dynamic method that produces more precise measurements than static methods. The solutions were analyzed with gas chromatography. A discrete-continuum solvation model was applied to investigate the influence of the solvent nature on the solubility of the compounds studied. It was shown that universal interactions between the solvent and the solute molecules, including the dispersive, inductive, and dipole-dipole interactions, dominate the solvation process. The dependences In x(298) similar to phi(alpha) and In x(298) similar to phi(mu) were obtained between the solubility logarithms at 298 K (In x(298)) and the parameters that determine the solute-solvent interactions for nonpolar (phi(mu)) and polar (phi(mu)) solvents, respectively. The role of the cavity formation energy in the solvation process was demonstrated. Finally, the correlation In x(298) = f(V-2) was suggested, where V-2 is the volume of a solute molecule in the solution.