Cone beam X-ray microtomography (XMT) instrumentation is a state-of-the-art non-invasive technology now used for several years to describe important characteristics of packed particle beds in three-dimensional (3D) detail. Many process engineering operations involve the transport of fluid in porous media. It is well known that the flow in porous media depends on the geometric properties of the pore network structure and in this regard X-ray microtomographic imaging captures the porous network structure of opaque packed particle beds which is later used for fluid flow analysis. The coupling of XMT 3D imaging with a novel fluid flow simulation method, known as the lattice-Boltzmann model (LBM), allows for direct local flow determination and micro-permeability calculations for complex Porous structures. In this paper the methodology is briefly explained, implementations for some practical problems are addressed, the application of the technique from results for packed particle beds of interest are presented, and a comparison with experimental data is made. (c) 2007 Taiwan Institute of Chemical Engineers. Published by Elsevier B.V. All rights reserved.