Sphingolipid E (SLE) is a synthesized sphingolipid on the model of ceramide. SLE plate particles could be produced via crystallization by cooling the SLE inch solution in the presence of supercritical carbon dioxide and were obtained as fine powder after depressurization. It was estimated that the particle aggregation was reduced by depressurization together with cooling. The obtained SLE plate particle powder contains no residual solvent and is pleasant to the touch, indicating its potential for use in cosmetics with moisturizing effect.