Dynamic light scattering (DLS) technique is used for characterizing the molecular changes in the physiological, chemical, polymer and colloidal systems, Since the first experimental use of the optical fiber in 1975, it has been increasingly important tool in the light scattering instrumentation, There had been a great amount of modification and development of this instrumentation during last couple of decades by so many researchers. Here we report the DLS study of polymer latices of different particle size and different concentration using various cells. The study shows that the quartz cell shows better efficiency than the acrylic cell for the latices of lower concentration. Analysis by FOQELS for concentrated solution of the latex of smaller particle size shows no deviation, Analysis of the latex of relatively larger particles shows negative deviation.