Tailor made Thermoplastic Elastomer (TPE) blends of commercial nitrile and acrylate rubbers with polyvinyl chloride, thermoplastic polyurethane and acrylonitrile styrene acrylate thermoplastic matrices, were investigated by Atomic Force Microscopy (AFM). Samples with surfaces flat at nanometric scale were prepared by injection and compression molding on freshly cleaved mica foils. The morphological and viscoelastic properties of the surfaces were mapped with nanometric resolution using the friction, tapping and phase contrast AFM modes. The AFM images show that in the investigated TPEs, the elastomers are homogeneously and finely dispersed within the thermoplastic matrix, thus confirming a high level of compatibility at the microscopic scale. The presence of rubber phase is identified at the outermost surface as well as in the bulk of the investigated blends. AFM is confirmed to be a very efficient tool for developing value added thermoplastic elastomer blends with better end use performances.