다제내성 슈퍼박테리아에 대한 새로운 항생제인 항균 펩타이드

박성철; 나재운; Seong-Cheol Park; Jae-Woon Nah

Applied Chemistry for Engineering, Vol.23, No.5, 429-432, October, 2012

Export Citation

다제내성 슈퍼박테리아에 대한 새로운 항생제인 항균 펩타이드

Antimicrobial Peptide as a Novel Antibiotic for Multi-Drug Resistance “Super-bacteria”

박성철^†, 나재운

순천대학교 공과대학교 고분자공학과

Seong-Cheol Park^†, and Jae-Woon Nah

Department of Polymer Science and Engineering, Sunchon National University, Suncheon 540-742, Korea

E-mail:

초록

최근 항생제에 대한 내성이 빠르게 확산됨에 따라 이를 극복하기 위해 새로운 항생제들을 찾기 위한 노력이 많은 연구자들에 의해 이루어지고 있다. 미생물의 외부공격에 대해 모든 생명체들은 방어물질을 분비하거나 내재하고 있는데 그 중 하나가 항균 펩타이드이며, 전 세계적으로 활발한 연구가 이루어지고 있고 새로운 차세대 항생제로써 인식되어진다. 이에 본 총설에서는 항균 펩타이드의 미생물에 대한 항생활성, 작용기작과 개발현황에 대해 고찰하고자 한다.

According to the requirement of novel antimicrobial agents for the rapidly increasing emergence of multi-drug resistant pathogenic microbes, a number of researchers have found new antibiotics to overcome this resistance. Among them, antimicrobial peptides (AMPs) are host defense molecules found in a wide variety of invertebrate, plant, and animal species, and are promising to new antimicrobial candidates in pharmatherapeutic fields. Therefore, this review introduces the antimicrobial action of antimicrobial peptide and ongoing development as a pharmetherapeutic agent.

Keywords:antimicrobial peptide;multi-drug resistance;biofilm;MRSA;lipopolysaccharide

[References]

Klevens RM, Edwards JR, Richards CL, Horan TC, Gaynes RP, Pollock DA, Cardo DM, Public Health Rep., 122, 160 (2007)
Yuji K, Oiso G, Matsumura T, Murashige N, Kami M, Clin. Infect. Dis., 52, 422 (2011)
Nordmann P, Poirel L, Walsh TR, Livermore DM, Trends Microbiol., 19, 588 (2011)
Hall-Stoodley L, Costerton JW, Stoodley P, Nat. Rev.Microbiol., 2, 95 (2004)
Stewart PS, Costerton JW, Lancet., 358, 135 (2001)
O’Grady NP, Aexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG, Masur H, MMWR Recomm.Rep., 51, 129 (2002)
Zasloff M, Nature., 415, 389 (2002)
Oppenheim JJ, Biragyn A, Kwak LW, Yang D, Ann.Rheum. Dis., 62, 1721 (2003)
Steiner H, Hultmark D, Engstrom A, Bennich H, Boman HG, Nature., 292, 246 (1981)
Shai Y, Biopolymers., 66, 236 (2002)
Hancock RE, Sahl HG, Nat. Biotechnol., 24, 1551 (2006)
Yeaman MR, Yount NY, Pharmacol. Rev., 55, 27 (2003)
Park SC, Park Y, Hahm KS, Int. J. Mol. Sci., 12(9), 5971 (2011)
Guo L, Lim KB, Poduje CM, Daniel M, Gunn JS, Hackett M, Miller SI, Cell., 95, 189 (1998)
Pieters RJ, Arnusch CJ, Breukink E, Protein Pept. Lett., 16, 736 (2009)
Wu M, Maier E, Benz R, Hancock RE, Biochemistry., 38, 7235 (1999)
Park SC, Kim JY, Jeong C, Yoo S, Park Y, Hahm KS, Biochim. Biophys. Acta., 1808, 171 (2011)
Nicias P, FEBS J., 276, 6483 (2009)
Kragol G, Lovas S, Varadi G, Condie BA, Hoffmann R, Otvos L, Biochemistry., 40, 3016 (2001)
Cho JH, Sung BH, Kim SC, Biochim. Biophys. Acta., 1788, 1564 (2009)
Gazit E, Miller IR, Biggin PC, Sansom MS, Shai Y, J. Mol. Biol., 258, 860 (1996)
Zasloff M, Proc. Natl. Acad. Sci. USA., 84, 5449 (1987)
Lee DG, Kim HN, Park Y, Kim HK, Choi BH, Choi CH, Hahm KS, Biochim. Biophys. Acta., 1598, 185 (2002)
Park Y, Park SC, Park HK, Shin SY, Kim Y, Hahm KS, Biopolymers., 88, 199 (2007)
Park SC, Kim MH, Hossain MA, Shin SY, Kim Y, Stella I, Wade JD, Park Y, Hahm KS, Biochim. Biophys.Acta., 1778, 229 (2008)
Lehrer RI, Ganz T, Curr. Opin. Immunol., 11, 23 (1999)
Hancock RE, Lancet., 349, 418 (1999)
Weinberg A, Krisanaprakornkit S, Dale BA, Crit. Rev. Oral Biol. Med., 9, 399 (1998)
Subbalakshmi C, Sitaram N, FEMS Microbiol. Lett., 160, 91 (1998)
Hsu CH, Chen C, Jou ML, Lee AY, Lin YC, Yu YP, Huang WT, Wu SH, Nucleic Acids Res., 33, 4053 (2005)
Rubinchik E, Dugourd D, Algara T, Pasetka C, Friedland HD, Int. J. Antimicrob. Agents., 34, 457 (2009)
Yeung AT, Gellatly SL, Hancock RE, Cell. Mol. Life Sci., 68, 2161 (2011)
Zaiou M, J. Mol. Med., 85, 317 (2007)

[Related Articles]

[1] Klevens RM, Edwards JR, Richards CL, Horan TC, Gaynes RP, Pollock DA, Cardo DM, Public Health Rep., 122, 160 (2007)

[2] Yuji K, Oiso G, Matsumura T, Murashige N, Kami M, Clin. Infect. Dis., 52, 422 (2011)

[3] Nordmann P, Poirel L, Walsh TR, Livermore DM, Trends Microbiol., 19, 588 (2011)

[4] Hall-Stoodley L, Costerton JW, Stoodley P, Nat. Rev.Microbiol., 2, 95 (2004)

[5] Stewart PS, Costerton JW, Lancet., 358, 135 (2001)

[6] O’Grady NP, Aexander M, Dellinger EP, Gerberding JL, Heard SO, Maki DG, Masur H, MMWR Recomm.Rep., 51, 129 (2002)

[7] Zasloff M, Nature., 415, 389 (2002)

[8] Oppenheim JJ, Biragyn A, Kwak LW, Yang D, Ann.Rheum. Dis., 62, 1721 (2003)

[9] Steiner H, Hultmark D, Engstrom A, Bennich H, Boman HG, Nature., 292, 246 (1981)

[10] Shai Y, Biopolymers., 66, 236 (2002)

[11] Hancock RE, Sahl HG, Nat. Biotechnol., 24, 1551 (2006)

[12] Yeaman MR, Yount NY, Pharmacol. Rev., 55, 27 (2003)

[13] Park SC, Park Y, Hahm KS, Int. J. Mol. Sci., 12(9), 5971 (2011)

[14] Guo L, Lim KB, Poduje CM, Daniel M, Gunn JS, Hackett M, Miller SI, Cell., 95, 189 (1998)

[15] Pieters RJ, Arnusch CJ, Breukink E, Protein Pept. Lett., 16, 736 (2009)

[16] Wu M, Maier E, Benz R, Hancock RE, Biochemistry., 38, 7235 (1999)

[17] Park SC, Kim JY, Jeong C, Yoo S, Park Y, Hahm KS, Biochim. Biophys. Acta., 1808, 171 (2011)

[18] Nicias P, FEBS J., 276, 6483 (2009)

[19] Kragol G, Lovas S, Varadi G, Condie BA, Hoffmann R, Otvos L, Biochemistry., 40, 3016 (2001)

[20] Cho JH, Sung BH, Kim SC, Biochim. Biophys. Acta., 1788, 1564 (2009)

[21] Gazit E, Miller IR, Biggin PC, Sansom MS, Shai Y, J. Mol. Biol., 258, 860 (1996)

[22] Zasloff M, Proc. Natl. Acad. Sci. USA., 84, 5449 (1987)

[23] Lee DG, Kim HN, Park Y, Kim HK, Choi BH, Choi CH, Hahm KS, Biochim. Biophys. Acta., 1598, 185 (2002)

[24] Park Y, Park SC, Park HK, Shin SY, Kim Y, Hahm KS, Biopolymers., 88, 199 (2007)

[25] Park SC, Kim MH, Hossain MA, Shin SY, Kim Y, Stella I, Wade JD, Park Y, Hahm KS, Biochim. Biophys.Acta., 1778, 229 (2008)

[26] Lehrer RI, Ganz T, Curr. Opin. Immunol., 11, 23 (1999)

[27] Hancock RE, Lancet., 349, 418 (1999)

[28] Weinberg A, Krisanaprakornkit S, Dale BA, Crit. Rev. Oral Biol. Med., 9, 399 (1998)

[29] Subbalakshmi C, Sitaram N, FEMS Microbiol. Lett., 160, 91 (1998)

[30] Hsu CH, Chen C, Jou ML, Lee AY, Lin YC, Yu YP, Huang WT, Wu SH, Nucleic Acids Res., 33, 4053 (2005)

[31] Rubinchik E, Dugourd D, Algara T, Pasetka C, Friedland HD, Int. J. Antimicrob. Agents., 34, 457 (2009)

[32] Yeung AT, Gellatly SL, Hancock RE, Cell. Mol. Life Sci., 68, 2161 (2011)

[33] Zaiou M, J. Mol. Med., 85, 317 (2007)