The synthesis of polyacrylamide (PAM) graft poly(ethylene oxide) (PEG) has been investigated and the reaction conditions were varied by gamma irradiation to optimize polystyrene latex flocculation by the copolymers. The effects of the gamma ray dosage, the PEO chain length, the ratio of PEO to PAM, and the crosslinking degree of copolymer were studied. The most effective flocculant was obtained by exposing a mixture of 1.2 wt % PAM (M(w) = 5 x 10(6)) and 0.94 wt % PEO (M(w) = 5000) to 816 krad of gamma radiation. The resulting copolymer contained 24 wt % PEG. Crosslinking to give insoluble gels was an undesirable side reaction increased with gamma-ray dose and decreased with PEO addition. The most effective flocculants contained more than 15 wt % PEO with little crosslinking. The grafting behavior of triblock copolymer, poly(ethyleneoxide)-b-poly(propyleneoxide)-b-poly(ethylene oxide) (E(m)P(n)E(m), where m and n are oxyethylene and oxypropylene unit, respectively), onto PAM by gamma radiation was also studied; grafting occurred but effective flocculants were not obtained.