A model relating the adhesive properties, and the complete molecular weight distribution of n-butyl acrylate/styrene latexes of fixed copolymer molar composition (85/15) was constructed using partial least squares regression (PLS-R). This quantitative relationship allows the prediction of the adhesive properties of the latexes from MWD measurements. After validation of the model, it was combined with a control strategy, which allows the production of latexes of controlled copolymer composition and MWD. The resulting system can be regarded as a method for the control of the adhesive properties of the latex. This methodology was satisfactorily validated experimentally by the production of two latexes of different adhesive performance.