Glucosyloxyethyl methacrylate (GEMA) was copolymerized with butyl acrylate (BA) for the preparation of a biomedical pressure-sensitive adhesive with pendant monosaccharides, for possible use in medical applications. The measurements of 180 degrees peel strength, ball tack, and holding power for the GEMA-BA copolymer films revealed that the film at the GEMA content of 5 mol % has excellent pressure-sensitive adhesive properties. Protein adsorption onto the GEMA-BA copolymer film hardly occurred due to very low interfacial free energy between its surface and water. Release profiles of vitamin B-12 from the GEMA-BA copolymer film suggests that it is useful as a material for a transdermal therapeutic system.