Ethylene oxide (EO), a valuable chemical feedstock in producing many industrial chemicals, which is industrially produced by the partial oxidation of ethylene, so-called ethylene epoxidation, has been of great interest in many global research studies. In this work, the epoxidation of ethylene under a low-temperature dielectric barrier discharge (DBD) was feasibly investigated to find the best operating conditions. It was experimentally found that the EO yield decreased with increasing O(2)/C(2)H(4) feed molar ratio, feed flow rate, input frequency, and electrode gap distance, while it increased with increasing applied voltage up to 19 kV. The highest EO yield of 5.6% was obtained when an input frequency of 500 Hz and an applied voltage of 19 kV were used, with an O(2)/C(2)H(4) feed molar ratio of 1: 1, a feed flow rate of 50 cm(3)/min, and an electrode gap distance of 10 mm. Under these best conditions, the power consumption was found to be as low as 6.07 x 9 10(-16) Ws/molecule of EO produced.