The reaction rate orders in components, the apparent rate constant, and the activation energy of the transesterification reaction of dibutyl adipate with a mixture of isomeric dioxane alcohols, the isoprene rubber manufacturing waste, were determined. The conditions for running the transesterification process aimed to obtain a poly(vinyl chloride) blend plasticizer are recommended. Gas chromatographic-mass spectrometric analysis data for the fraction of dioxane alcohols and a mixture of their esters are presented.