The hydroisomerization of n-dodecane on bifunctional catalysts with mesostructured aluminosilicates as an active component has been studied. Aluminosilicates with an Si/Al atomic ratio of 5 to 48 have been prepared using hexadecylamine as a template. Catalyst supports contained 35 wt % mesoporous material and 65 wt % gamma-Al2O3. The platinum loading of the catalysts was 0.5% of the support mass. It has been found that the catalysts based on mesoporous aluminosilicates with an Si/Al ratio of 10 and 22 exhibit the highest selectivity. In their presence, the conversion reaches 43-46 wt % with the selectivity for iso-C12H26 of more than 90%.