A number of cyclones with different exit tube diameters have been simulated with CFD in this study. Results show that the exit tube diameter influences not only the velocity magnitude, but also the shape of the velocity profiles within cyclones. Depending on the diameter of the exit tube, the axial velocity profiles can exhibit a either maximum or a minimum on the axis. If the exit tube diameter is small, the central flow has a jet-like appearance. On the other hand, axial velocity dip in the profile can be observed near the center in a cyclone with a large gas exit tube. In addition, the well-known double vortexes, which commonly are present in a cyclone of practical design, do not exist in a cyclone with an excessively large exit tube. Quantitative comparison of velocity distribution shows that the tangential velocity increases as the exit tube diameter is reduced, giving rise to higher particle collection efficiency. Usually, the pressure drop decreases with increasing exit tube diameter. However, if the exit tube size is excessively large, the pressure drop may start to increase. Practically, cyclone with an excessively large exit tube should be avoided.