This article describes the hydrolytic degradation of a series of nylons based on methylated L-tartaric acid and diamines. These polytartaramides were prepared by a solution poly condensation process using bis(pentachlorophenyl)-2,3-O-dimethyl-L-tartrate and N,N’-bis(trimethylsilyl)alkanediamines with 6, 8, or 12 methylene groups. The stereoregular optically active polyamides obtained were soluble in chloroform and showed intrinsic viscosities between 1.0 and 2.7 dL g(-1). The degradation of these polytartaramides in the form of discs has been investigated in buffered salt solutions of pH 2.3, 7.4, and 10.6, and at temperatures of 37, 55, and 70 degrees C. The degradation was monitored by following the changes in molecular weight, mass loss, chemical constitution, and thermal properties. Our results show that these polytartaramides degrade slowly at 37 degrees C, with a degradation rate highly depending upon the number of methylenes in the diamine unit of the polyamide. The pH of the medium has also a great influence on degradation, as well as the temperature, with an important hydrolysis rate enhancement at 70 degrees C.