The transient advection of a cylindrical vortex tube in a viscous incompressible flow field and its interaction with a rotating/spinning spherical particle has been investigated numerically at Reynolds numbers in the range of 20 less than or equal to Re less than or equal to 200 for angular velocities of 0 less than or equal to Omega less than or equal to 0.5. The effects of vortex parameters such as size, circulation strength and initial position relative to the particle, on the temporal behavior of the lift and drag forces are studied. Vortex-sphere interactions bring about major changes in the flow field particularly when coupled with particle rotation. It is observed that the forces acting on the particle are significantly influenced during the time that the vortex core is in the vicinity of the particle. The extent of these local changes are about +/-30% in the drag coefficient and about +/-200% in the lift coefficient as compared to flow over a rotating solid sphere with no vortex interaction. It is also found that a vortex with core radius between one and two particle diameters creates the strongest temporal variations in the lift and drag coefficients. Furthermore, maximum lift variations occur for the vortex-particle head on collision, while a vortex with an offset distance of about one diameter from the principal flow axis generates the maximum drag variations.