Since the 1980s, various types of accidents, such as fire, explosion, and toxic release, have occurred in science parks (SCs) in Taiwan. The aftermath included financial losses, damaged reputations, business and operation interruption, property damage, and loss of lives. Considering loss prevention, this study plans an emergency response centre (ERC) in order to properly and proactively cope with incidents occurring in the Southern Taiwan Science Park (STSIP) since its inception in 1996. This article also design and promulgate the use of central monitoring system (CMS) between the ERC and various plants located in the STSIP. With a view to alleviating hazards, the integrated CMS could comprehensively bring a safer environment to all workers and staff at STSIP. Only through the reviews of table-top or functional exercise and real accidents, a comprehensive, fail-safe, and real-life system could be establish to lessen the hazards in STSIP.