In an ever changing business environment, enterprise-wide and plant site-based training initiatives take on added importance. There are training requirements to address process safety management (PSM), risk management, security, and EHS needs and regulations, as well as training programs to address related internal company and business focused directives and initiatives. These ever-changing topics and increasing requirements present ample challenges to companies attempting to provide quality training to their work force for performance improvement. Much has been written regarding the promise of e-learning technologies in meeting these needs. However, technology itself will not solve training challenges. Training programs built using a formal, structured approach, such as instructional systems design (ISD) ensures that a highly effective, quality training program is built and consistently delivered. ISD utilizes the following sequential steps: analysis, design, development, implementation, and evaluation. Use of ISD assures that the proper target audience and specific instructional needs arc, identified, instructional objectives are established, an appropriate instructional strategy is selected, and the evaluation strategy is devised and implemented. This article outlines use of ISD to create and deliver highly effective training programs, and includes a review of new training technologies. (c) 2007 American Institute of Chemical Engineers.