화학공학소재연구정보센터
Przemysl Chemiczny, Vol.91, No.3, 303-305, 2012
Efficient synthesis of nepafenac via modified Gassman reaction
Known synthesis of 2-amino-3-benzoyl-alpha-(methylthio)phenylacetamide (nepafenac intermediate) was improved by using N-chlorophthalimide or 1,3-dichloro-5,5-dimethyl-hydantoin as chlorination reagents. The product showed a purity of above 98%.