Peripherally Applied A beta-Containing Inoculates Induce Cerebral beta-Amyloidosis

Eisele YS; Obermuller U; Heilbronner G; Baumann F; Kaeser SA; Wolburg H; Walker LC; Staufenbiel M; Heikenwalder M; Jucker M

Science, Vol.330, No.6006, 980-982, 2010

DOI10.1126/science.1194516 Export Citation

Peripherally Applied A beta-Containing Inoculates Induce Cerebral beta-Amyloidosis

Eisele YS, Obermuller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H, Walker LC, Staufenbiel M, Heikenwalder M, Jucker M

The intracerebral injection of beta-amyloid-containing brain extracts can induce cerebral beta-amyloidosis and associated pathologies in susceptible hosts. We found that intraperitoneal inoculation with beta-amyloid-rich extracts induced beta-amyloidosis in the brains of beta-amyloid precursor protein transgenic mice after prolonged incubation times.