Gel formation of a water-soluble zwitterionic phosphatidylcholine analogous acrylamide monomer, 1-(acrylamidomethyl)-2’-(trimethylammonio)ethyl phosphate (AMP), ws examined using N,N’-methylenebisacrylamide as the crosslinking constituent, ammonium persulfate as the initiator, and N,N,N’,N’-tetramethyl ethylene diamine as the accelerator at room temperature in water system. The swelling properties of the synthesized hydrogel AMPG were investigated in distilled water at different temperatures, in water-acetone medium with different volume ratios, or in different inorganic salts aqueous of various compositions. Furthermore, lysozyme release behavior of the gel was found to depend on the composition of immersed solutions.