A relationship between heat generation of filled rubber vulcanizates and hysteresis loss, specific heat, thermal conductivity, modulus, filler loading, structure, and surface area of the filler, the temperature difference between application temperature and glass transition temperature, frequency, temperature difference between the wall and the environment, stress, and stroke amplitude were developed. Styrene-butadiene rubber (SBR) and natural rubber (NR) vulcanizates were used that had variations of loading of carbon black, silica, resin and coupling agent, types of filler, level of curatives, and cure time. The derived equation was verified with a set of a few unknown SBR and NR vulcanizates, and also by varying the stress and stroke amplitudes in the heat generation experiment.