Molecular Chaperone-Like Hyaluronic Acid Nanoparticles: Implications as the Carrier for Protein Delivery Systems

Maharajan Sivasubramanian; Ah Reum Kang; Hwa Seung Han; Roun Heo; Joon-Youl Lee; Kap Jin Kim; Sang Min Jeon; Su Young Chae; Dong-Gyu Jo; Jong-Ho Kim; Jae Hyung Park

Macromolecular Research, Vol.20, No.10, 1007-1010, October, 2012

DOI10.1007/s13233-012-0158-3 Export Citation

Molecular Chaperone-Like Hyaluronic Acid Nanoparticles: Implications as the Carrier for Protein Delivery Systems

Maharajan Sivasubramanian¹, Ah Reum Kang¹, Hwa Seung Han¹, Roun Heo¹, Joon-Youl Lee¹, Kap Jin Kim¹, Sang Min Jeon², Su Young Chae³, Dong-Gyu Jo^{3, 4}, Jong-Ho Kim^{5, †}, and Jae Hyung Park^{2, 4, †}

¹Department of Advanced Polymer and Fiber Materials, Kyung Hee University, Gyeonggi, 446-701, Korea
²Department of Polymer Science and Engineering, College of Engineering, Sungkyunkwan University, Gyeonggi, 440-746, Korea
³College of Pharmacy, Sungkyunkwan University, Gyeonggi, 440-746, Korea
⁴Graduate School of Health Sciences and Technology, Sungkyunkwan University, Gyeonggi, 440-746, Korea
⁵College of Pharmacy, Kyung Hee University, Seoul, 130-701, Korea

E-mail:,

[References]

Leader B, Baca QJ, Golan DE, Nat. Rev. Drug Discov., 7, 21 (2008)
Egrie JC, Browne JK, Br. J. Cancer., 84, 3 (2001)
Langer R, Science., 249, 1527 (1990)
Sinha VR, Trehan A, J. Control. Release., 90, 261 (2003)
Sun L, Zhou S, Wang W, Li X, Wang J, Weng J, Colloids Surf. A: Physiochem. Eng. Asp., 345, 173 (2009)
Fu K, Klibanov AM, Langer R, Nat. Biotechnol., 18, 24 (2000)
Fu K, Pack DW, Kilbanov AM, Langer R, Pharm.Res., 17, 100 (2000)
Gething MJ, Sambrook J, Nature., 355, 33 (1992)
Hartl FU, Nature, 381(6583), 571 (1996)
Ranson NA, White HE, Saibil HR, Biochem. J., 333, 223 (1998)
Cohen FE, Kelly JW, Nature., 426, 905 (2003)
Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamisligil GS, Science., 313, 1137 (2006)
Morimoto N, Endo T, Iwasaki Y, Akiyoshi K, Biomacromolecules, 6(4), 1829 (2005)
Nomura Y, Ikeda M, Yamaguchi N, Aoyama Y, Akiyoshi K, Febs Lett., 553, 271 (2003)
Nomura Y, Sasaki Y, Takagi M, Narita T, Aoyama Y, Akiyoshi K, Biomacromolecules, 6(1), 447 (2005)
Kim JH, Kim YS, Park K, Lee S, Nam HY, Min KH, Jo HG, Park JH, Choi K, Jeong SY, Park RW, Kim IS, Kim K, Kwon IC, J. Control. Release., 127, 41 (2008)
Kim K, Kim JH, Kim S, Chung H, Choi K, Kwon IC, Park JH, Kim YS, Park RW, Kim IS, Jeong YS, Macromol. Res., 13(3), 167 (2005)
Li L, Moon HT, Park JY, Heo YJ, Choi Y, Tran TH, Lee Y, Kim SY, Huh KM, Macromol. Res., 19(5), 487 (2011)
Kim H, Na K, Macromol. Res., 18(8), 812 (2010)
Choi KY, Min KH, Na JH, Choi K, Kim K, Park JH, Kwon IC, Jeong SY, J. Mater. Chem., 19, 4102 (2009)
Choi KY, Chung H, Min KH, Yoon HY, Kim K, Park JH, Kwon IC, Jeong SY, Biomaterials., 31, 106 (2010)
Saravanakumar G, Choi KY, Yoon HY, Kim K, Park JH, Kwon IC, Park K, Int. J. Pharm., 394, 154 (2010)
Choi KY, Min KH, Yoon HY, Kim K, Park JH, Kwon IC, Choi K, Jeong SY, Biomaterials., 32, 1880 (2011)
Choi KY, Yoon HY, Kim JH, Bae SM, Park RW, Kang YM, Kim IS, Kwon IC, Choi K, Jeong SY, Kim K, Park JH, ACS Nano., 5, 8591 (2011)
Pocker Y, Stone JT, Biochemistry., 6, 668 (1967)
Putney S, Burke PA, Nat. Biotechnol., 16, 153 (1998)
Kim YJ, Chae SY, Jin CH, Sivasubramanian M, Son S, Choi KY, Jo DG, Kim K, Kwon IC, Lee KC, Park JH, Biomaterials., 31, 9057 (2010)
Na SJ, Chae SY, Lee S, Park K, Kim K, Park JH, Kwon IC, Jeong SY, Lee KC, Int. J. Pharm., 363, 149 (2008)
Van Tomme SR, Van Steenbergen MJ, De Smedt SC, Van Nostrum CF, Hennik WE, Biomaterials., 26, 2129 (2005)
Lokeshwar VB, Lokeshwar BL, Pham HT, Block NL, Cancer Res., 56, 651 (1996)
Chao KL, Muthukumar L, Herzberg O, Biochemistry., 46, 6911 (2007)
Franzmann EJ, Schroeder GL. Goodwin WJ, Weed DT, Fisher P, Lokeshwar VB, Int. J. Cancer., 106, 438 (2003)
Veronese FM, Pasut G, Drug Discov. Today., 10, 1451 (2005)
Chae SY, Kim TH, Park K, Jin CH, Son S, Lee S, Youn YS, Kim K, Jo DG, Kwon IC, Chen X, Lee KC, Mol. Cancer Ther., 9, 1719 (2010)
Harris JM, Chess RB, Nat. Rev. Drug Discov., 2, 214 (2003)
Cheng T, Wu PY, Wu MF, Chern JW, Roffler SR, Bioconjug. Chem., 10, 520 (1999)
Ganson NJ, Kelly SJ, Scarlett E, Sundy JS, Hershfield MS, Arthritis Res. Ther., 8, R12 (2005)
Ishida T, Atobe K, Wang XY, Kiwada H, J. Control.Release., 115, 251 (2006)

[Related Articles]

[1] Leader B, Baca QJ, Golan DE, Nat. Rev. Drug Discov., 7, 21 (2008)

[2] Egrie JC, Browne JK, Br. J. Cancer., 84, 3 (2001)

[3] Langer R, Science., 249, 1527 (1990)

[4] Sinha VR, Trehan A, J. Control. Release., 90, 261 (2003)

[5] Sun L, Zhou S, Wang W, Li X, Wang J, Weng J, Colloids Surf. A: Physiochem. Eng. Asp., 345, 173 (2009)

[6] Fu K, Klibanov AM, Langer R, Nat. Biotechnol., 18, 24 (2000)

[7] Fu K, Pack DW, Kilbanov AM, Langer R, Pharm.Res., 17, 100 (2000)

[8] Gething MJ, Sambrook J, Nature., 355, 33 (1992)

[9] Hartl FU, Nature, 381(6583), 571 (1996)

[10] Ranson NA, White HE, Saibil HR, Biochem. J., 333, 223 (1998)

[11] Cohen FE, Kelly JW, Nature., 426, 905 (2003)

[12] Ozcan U, Yilmaz E, Ozcan L, Furuhashi M, Vaillancourt E, Smith RO, Gorgun CZ, Hotamisligil GS, Science., 313, 1137 (2006)

[13] Morimoto N, Endo T, Iwasaki Y, Akiyoshi K, Biomacromolecules, 6(4), 1829 (2005)

[14] Nomura Y, Ikeda M, Yamaguchi N, Aoyama Y, Akiyoshi K, Febs Lett., 553, 271 (2003)

[15] Nomura Y, Sasaki Y, Takagi M, Narita T, Aoyama Y, Akiyoshi K, Biomacromolecules, 6(1), 447 (2005)

[16] Kim JH, Kim YS, Park K, Lee S, Nam HY, Min KH, Jo HG, Park JH, Choi K, Jeong SY, Park RW, Kim IS, Kim K, Kwon IC, J. Control. Release., 127, 41 (2008)

[17] Kim K, Kim JH, Kim S, Chung H, Choi K, Kwon IC, Park JH, Kim YS, Park RW, Kim IS, Jeong YS, Macromol. Res., 13(3), 167 (2005)

[18] Li L, Moon HT, Park JY, Heo YJ, Choi Y, Tran TH, Lee Y, Kim SY, Huh KM, Macromol. Res., 19(5), 487 (2011)

[19] Kim H, Na K, Macromol. Res., 18(8), 812 (2010)

[20] Choi KY, Min KH, Na JH, Choi K, Kim K, Park JH, Kwon IC, Jeong SY, J. Mater. Chem., 19, 4102 (2009)

[21] Choi KY, Chung H, Min KH, Yoon HY, Kim K, Park JH, Kwon IC, Jeong SY, Biomaterials., 31, 106 (2010)

[22] Saravanakumar G, Choi KY, Yoon HY, Kim K, Park JH, Kwon IC, Park K, Int. J. Pharm., 394, 154 (2010)

[23] Choi KY, Min KH, Yoon HY, Kim K, Park JH, Kwon IC, Choi K, Jeong SY, Biomaterials., 32, 1880 (2011)

[24] Choi KY, Yoon HY, Kim JH, Bae SM, Park RW, Kang YM, Kim IS, Kwon IC, Choi K, Jeong SY, Kim K, Park JH, ACS Nano., 5, 8591 (2011)

[25] Pocker Y, Stone JT, Biochemistry., 6, 668 (1967)

[26] Putney S, Burke PA, Nat. Biotechnol., 16, 153 (1998)

[27] Kim YJ, Chae SY, Jin CH, Sivasubramanian M, Son S, Choi KY, Jo DG, Kim K, Kwon IC, Lee KC, Park JH, Biomaterials., 31, 9057 (2010)

[28] Na SJ, Chae SY, Lee S, Park K, Kim K, Park JH, Kwon IC, Jeong SY, Lee KC, Int. J. Pharm., 363, 149 (2008)

[29] Van Tomme SR, Van Steenbergen MJ, De Smedt SC, Van Nostrum CF, Hennik WE, Biomaterials., 26, 2129 (2005)

[30] Lokeshwar VB, Lokeshwar BL, Pham HT, Block NL, Cancer Res., 56, 651 (1996)

[31] Chao KL, Muthukumar L, Herzberg O, Biochemistry., 46, 6911 (2007)

[32] Franzmann EJ, Schroeder GL. Goodwin WJ, Weed DT, Fisher P, Lokeshwar VB, Int. J. Cancer., 106, 438 (2003)

[33] Veronese FM, Pasut G, Drug Discov. Today., 10, 1451 (2005)

[34] Chae SY, Kim TH, Park K, Jin CH, Son S, Lee S, Youn YS, Kim K, Jo DG, Kwon IC, Chen X, Lee KC, Mol. Cancer Ther., 9, 1719 (2010)

[35] Harris JM, Chess RB, Nat. Rev. Drug Discov., 2, 214 (2003)

[36] Cheng T, Wu PY, Wu MF, Chern JW, Roffler SR, Bioconjug. Chem., 10, 520 (1999)

[37] Ganson NJ, Kelly SJ, Scarlett E, Sundy JS, Hershfield MS, Arthritis Res. Ther., 8, R12 (2005)

[38] Ishida T, Atobe K, Wang XY, Kiwada H, J. Control.Release., 115, 251 (2006)