Control of Drug Release Behavior of pH-Responsive PVA/PAAc Hydrogel by Surface Modification with Oxyfluorination

Jumi Yun; Ae-Ri Oh; Ji Sun Im; Hyung-Il Kim; Young-Seak Lee

Macromolecular Research, Vol.20, No.10, 1029-1036, October, 2012

DOI10.1007/s13233-012-0146-7 Export Citation

Control of Drug Release Behavior of pH-Responsive PVA/PAAc Hydrogel by Surface Modification with Oxyfluorination

Jumi Yun, Ae-Ri Oh, Ji Sun Im, Hyung-Il Kim^†, and Young-Seak Lee

Department of Fine Chemical Engineering and Applied Chemistry, BK21-E2M, Chungnam National University, Daejeon, 305-764, Korea

E-mail:

The pH-responsive poly(vinyl alcohol)/poly(acrylic acid) hydrogel was prepared as a drug-delivery carrier. The drug release rate from hydrogels was controlled by surface modification with oxyfluorination. The oxyfluorination in higher oxygen content produced more hydrophilic hydrogel surface area. In contrast, the fluorination with fluorine gas produced more hydrophobic hydrogel surface area. C-O bonds and C-F bonds were mainly formed by oxyfluorination and fluorination, respectively. Both the swelling ratio and the drug release rate were strongly dependent on the oxyfluorination conditions. The drug release was accelerated by oxyfluorination in higher oxygen content because the favorable affinity at the interface caused the higher swelling ratio; whereas, the sustained drug release was obtained by fluorination because of the lower swelling ratio of the hydrophobically modified hydrogels.

Keywords:controlled release;pH-responsive;hydrogel;oxyfluorination;surface modification.

[References]

Aguzzi C, Cerezo P, Viseras C, Caramella C, Appl.Clay Sci., 36, 22 (2007)
Haznedar S, Dortunc B, Int. J. Pharm., 269, 31 (2004)
Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM, Chem. Rev., 99(11), 3181 (1999)
Plunkett KN, Berkowski KL, Moore JS, Biomacromolecules, 6(2), 632 (2005)
Bhattarai N, Ramay HR, Gunn J, Matsen FA, Zhang M, J. Control. Release., 103, 609 (2005)
Alarcon CDL, Penndam S, Alexander C, Chem. Soc.Rev., 34, 276 (2005)
Schilli CM, Zhang MF, Rizzardo E, Thang SH, Chong YK, Edwards K, Karlsson G, Muller AHE, Macromolecules, 37(21), 7861 (2004)
Zhang XZ, Yang YY, Chung TS, Ma KX, Langmuir, 17(20), 6094 (2001)
Bajpai AK, Shukla SK, Bhanu S, Kankane S, Prog.Polym. Sci., 33, 1088 (2008)
Alias J, Goni I, Gurruchaga M, Polym. Degrad. Stab., 92, 658 (2007)
Alias J, Silva I, Goni I, Gurruchaga M, Carbohydr.Polym., 74, 31 (2008)
Echeverria I, Silva I, Goni I, Gurruchaga M, J. Appl. Polym. Sci., 96(2), 523 (2005)
Lecomte F, Siepmann J, Walther M, MacRae RJ, Bodmeier R, Pharm. Res., 22, 1129 (2005)
Yun J, Im JS, Lee YS, Bae TS, Lim YM, Kim HI, Colloids Surf. A: Physicochem. Eng. Asp., 368, 23 (2010)
Yun J, Im JS, Lee YS, Kim HI, Eur. Polym. J., 46, 900 (2010)
Lee YS, Yoon S, Yoon HJ, Lee K, Yoon HK, Lee JH, Toxicol. Lett., 189, 191 (2009)
Im JS, Kim JG, Lee YS, Carbon., 47, 2640 (2009)
Park SJ, Kim BJ, J. Colloid Interface Sci., 291(2), 597 (2005)
Park SJ, Song SY, Shin JS, Rhee JM, J. Colloid Interface Sci., 283(1), 190 (2005)
Chamssedine F, Claves D, Carbon., 46, 957 (2008)
Beamson G, High Resolution XPS of Organic Polymers, Wiley, New York (1992)
Park SJ, Jeong HJ, Nah C, Mater. Sci. Eng. A., 385, 13 (2004)
Guerinoa M, Massia M, Mansanob RD, Microelectron.J., 38, 915 (2007)
Mathur AM, Moorjani SK, Scranton AB, Polym.Rev., 36, 405 (1996)
Karadag E, Saraydin D, Sahiner N, Guven O, J. Macromol. Sci. A., 38, 1105 (2001)
Lim JW, Lee JM, Yun SM, Park BJ, Lee YS, J. Ind. Eng. Chem., 15(6), 876 (2009)
Im JS, Bai BC, Bae TS, In SJ, Lee YS, Mater. Chem. Phys., 126(3), 685 (2011)
Yun J, Im JS, Kim HI, Lee YS, Appl. Surf. Sci., 258(8), 3462 (2012)
Berger J, Reist M, Mayer JM, Felt O, Peppas NA, Gurny R, Eur. J. Pharm. Biopharm., 57, 19 (2004)
Leanirith Y, Bunel C, Vairon JP, Macromol. Chem. Phys., 191, 1119 (1990)

[Referenced By]

[Related Articles]

[1] Aguzzi C, Cerezo P, Viseras C, Caramella C, Appl.Clay Sci., 36, 22 (2007)

[2] Haznedar S, Dortunc B, Int. J. Pharm., 269, 31 (2004)

[3] Uhrich KE, Cannizzaro SM, Langer RS, Shakesheff KM, Chem. Rev., 99(11), 3181 (1999)

[4] Plunkett KN, Berkowski KL, Moore JS, Biomacromolecules, 6(2), 632 (2005)

[5] Bhattarai N, Ramay HR, Gunn J, Matsen FA, Zhang M, J. Control. Release., 103, 609 (2005)

[6] Alarcon CDL, Penndam S, Alexander C, Chem. Soc.Rev., 34, 276 (2005)

[7] Schilli CM, Zhang MF, Rizzardo E, Thang SH, Chong YK, Edwards K, Karlsson G, Muller AHE, Macromolecules, 37(21), 7861 (2004)

[8] Zhang XZ, Yang YY, Chung TS, Ma KX, Langmuir, 17(20), 6094 (2001)

[9] Bajpai AK, Shukla SK, Bhanu S, Kankane S, Prog.Polym. Sci., 33, 1088 (2008)

[10] Alias J, Goni I, Gurruchaga M, Polym. Degrad. Stab., 92, 658 (2007)

[11] Alias J, Silva I, Goni I, Gurruchaga M, Carbohydr.Polym., 74, 31 (2008)

[12] Echeverria I, Silva I, Goni I, Gurruchaga M, J. Appl. Polym. Sci., 96(2), 523 (2005)

[13] Lecomte F, Siepmann J, Walther M, MacRae RJ, Bodmeier R, Pharm. Res., 22, 1129 (2005)

[14] Yun J, Im JS, Lee YS, Bae TS, Lim YM, Kim HI, Colloids Surf. A: Physicochem. Eng. Asp., 368, 23 (2010)

[15] Yun J, Im JS, Lee YS, Kim HI, Eur. Polym. J., 46, 900 (2010)

[16] Lee YS, Yoon S, Yoon HJ, Lee K, Yoon HK, Lee JH, Toxicol. Lett., 189, 191 (2009)

[17] Im JS, Kim JG, Lee YS, Carbon., 47, 2640 (2009)

[18] Park SJ, Kim BJ, J. Colloid Interface Sci., 291(2), 597 (2005)

[19] Park SJ, Song SY, Shin JS, Rhee JM, J. Colloid Interface Sci., 283(1), 190 (2005)

[20] Chamssedine F, Claves D, Carbon., 46, 957 (2008)

[21] Beamson G, High Resolution XPS of Organic Polymers, Wiley, New York (1992)

[22] Park SJ, Jeong HJ, Nah C, Mater. Sci. Eng. A., 385, 13 (2004)

[23] Guerinoa M, Massia M, Mansanob RD, Microelectron.J., 38, 915 (2007)

[24] Mathur AM, Moorjani SK, Scranton AB, Polym.Rev., 36, 405 (1996)

[25] Karadag E, Saraydin D, Sahiner N, Guven O, J. Macromol. Sci. A., 38, 1105 (2001)

[26] Lim JW, Lee JM, Yun SM, Park BJ, Lee YS, J. Ind. Eng. Chem., 15(6), 876 (2009)

[27] Im JS, Bai BC, Bae TS, In SJ, Lee YS, Mater. Chem. Phys., 126(3), 685 (2011)

[28] Yun J, Im JS, Kim HI, Lee YS, Appl. Surf. Sci., 258(8), 3462 (2012)

[29] Berger J, Reist M, Mayer JM, Felt O, Peppas NA, Gurny R, Eur. J. Pharm. Biopharm., 57, 19 (2004)

[30] Leanirith Y, Bunel C, Vairon JP, Macromol. Chem. Phys., 191, 1119 (1990)