화학공학소재연구정보센터
홈 로그인 로그아웃 연락처 사이트맵
Macromolecular Research, Vol.20, No.10, 1063-1069, October, 2012
DOI10.1007/s13233-012-0152-9  Export Citation
Biomimetic Surface Modification of Polycarbonateurethane Film via Phosphorylcholine-Graft for Resisting Platelet Adhesion
Wei Gao1, Yakai Feng1, 2, †, Jian Lu1, 3, Musammir Khan1, 3, and Jintang Guo1, 2, †
  • 1School of Chemical Engineering and Technology, Tianjin University, Weijin Road 92, Tianjin, 300072, P. R. China
  • 2Tianjin University-Helmholtz-Zentrum Geesthacht, Joint Laboratory for Biomaterials and Regenerative Medicine, Weijin Road 92, 300072, Tianjin, P. R. China
  • 3, China
E-mail:,
Phosphorylcholine groups were covalently introduced onto a polycarbonateurethane (PCU) surface in order to create a biomimetic structure on the polymer surfaces. After introducing primary amine groups onto the polymer surface by 1,6-hexanediamine, phosphorylcholine groups were covalently linked onto the surface by the reductive amination between the amino group and the aldehyde group of phosphorylcholine glyceraldehyde (PCGA). The results of water contact angle test, X-ray photoelectron spectroscopy (XPS), and X-ray fluorescence spectrometer (XRF) analysis of the modified films indicated that PCGA had already been covalently linked to the PCU surface. The topographies and surface roughnesses were both imaged and measured by atomic force microscopy (AFM). Scanning electron microscopy (SEM) observation of the PCU films after treatment with platelet-rich plasma demonstrated that platelets had rarely adhered to the surface of the PCGA-grafted PCU films but had mainly adhered to the surface of the blank PCU films. The platelet adhesion result indicated that the PC modified PCU films could resist platelet adhesion after grafting with PCGA, and that these PCGA-grafted PCU materials, potentially, might be applied as blood-contacting materials.
Keywords:polycarbonateurethane;biomimetic;surface modification;phosphorylcholine glyceraldehydes;platelet adhesion.
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