Enhanced transdermal deposition and characterization of quercetin-loaded ethosomes

Soo Nam Park; Hye Jin Lee; Hae Soo Kim; Min A Park; Hyun A Gu

Korean Journal of Chemical Engineering, Vol.30, No.3, 688-692, March, 2013

DOI10.1007/s11814-012-0171-4 Export Citation

Enhanced transdermal deposition and characterization of quercetin-loaded ethosomes

Soo Nam Park^†, Hye Jin Lee, Hae Soo Kim, Min A Park, and Hyun A Gu

Department of Fine Chemistry, Cosmetic R&D Center, Seoul National University of Science and Technology, 232, Gongreung-ro, Nowon-gu, Seoul 139-743, Korea

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We sought to evaluate the transdermal permeation potential of quercetin-loaded ethosomes. Quercetinloaded ethosomes were prepared and characterized with regard to particle size, loading efficiency, stability, and in vitro skin permeation. The optimized formulation of ethosomes was confirmed using 2% egg phosphatidylcholine and hydrated 20% ethanol. After quercetin was applied using this formulation, the stability of the ethosomes was determined when loaded with up to 0.04% quercetin. We observed that loading efficiency was improved with increasing concentrations of quercetin. Ethosomes loaded with 0.04% quercetin showed both the greatest loading efficiency (63.9%± 6.0%) and an optimal size range (132±32 nm). Ethosomes loaded with quercetin were superior in skin permeation ability (29.5±7.0 μg/cm2) compared to either ethanolic solution or liposomes. Therefore, we concluded that quercetin-loaded ethosomes increased the skin delivery of quercetin. Our results suggest that quercetin-loaded ethosomes may enhance the effect of cosmetic materials.

Keywords:Ethosomes;Quercetin;Transdermal;Skin Permeation Studies;Cosmetics

[References]

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Elsayed MMA, Abdallah OY, Naggar VF, Khalafallah NM, Int. J. Pharm., 332, 1 (2007)
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Park CI, Kang TJ, Lee SJ, Korean Chem. Eng. Res., 41, 598 (2003)
Yang HJ, Ahn YJ, Kim JH, Park SN, J. Soc. Cosmet. Scientists Korea., 34, 189 (2008)
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Park C, So HS, Shin CH, Baek SH, Moon BS, Shin SH, Lee HS, Lee DW, Park PK, Biochem. Pharmacol., 66, 1287 (2003)
Laughton MJ, Evans PJ, Moroney MA, Hoult JR, Halliwell B, Biochem. Pharmacol., 42, 1673 (1991)
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Fang YP, Tsai YH, Wu PC, Huang YB, Int. J. Pharm., 356, 144 (2008)
Paolino D, Lucania G, Mardente D, Alhaique F, Fresta M, J.Control. Release., 106, 99 (2005)
Fang YP, Huang YB, Wu PC, Tsai YH, Eur. J. Pharm.Biopharm., 73, 391 (2009)
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Jin BS, Lee SM, Lee KH, J. Korean Ind. Eng. Chem., 17(2), 138 (2006)

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