So far, molecularly imprinted polymers (MIPs) have been synthesized and evaluated as selective matrices for single components. It may be possible to impart multiple recognition sites in MIPs, which could be used as elements capable of binding more than one component. Such systems could advantageously be used in the design of sensors having the ability to sense more than one compound at a time. This communication discusses such a possibility by imprinting sites for two model compounds, namely, salicylic acid and hydrocortisone in poly(2-hydroxy ethyl methacrylate).