Synthesis of norbornene derived phosphonate (1), poly-D-lysine (2), and phopholipid (3) monomers and their complete characterizations are studied. Ring-opening metathesis polymerizations (ROMP) of monomers (1-3) produce well-defined copolymers, CP1 and CP2. H-1 NMR along with FT-IR spectroscopy characterization confirms the copolymer formation, while gel permeation chromatography (GPC) analysis suggests the formation of polymers with fairly narrow molecular weight distributions. Upon following the well-known ligand exchange methods these copolymers produce CdSe-bound copolymers, CP3 and CP4. Dynamic light scattering and transmission electron microscopy measures the size of these CdSe bound copolymers, while P-31 NMR suggests the formation of CP3 and CP4. The results from the experiments of these copolymers on Neuro2A cells suggest that the novel PDL-anchored nanomaterial show their ability to polarize neuronal growth and differentiation.