화학공학소재연구정보센터
Biotechnology Letters, Vol.34, No.11, 2083-2086, 2012
Photobiocatalyzed asymmetric reduction of ketones using Chlorella sp MK201
Aromatic ketones were reduced using suspension culture of Chlorella sp. MK201 under fluorescent light illumination producing the corresponding chiral alcohols in high yields with excellent enantiomeric excess (ee). For example, 2',3',4',5',6'-pentafluoroacetophenone at 0.25 mg/ml was converted to the corresponding (S)-alcohol in 80 % yield with >99 % ee by 1 mg dry wt of Chlorella/ml in 12 h illumination (2,000 lux).