Short peptides with or without host guest-bridges on their side chains were prepared and the helix content was examined in the absence or in the presence of the host guest-bridge breaker. While a short peptide without host guest-bridge had 14% helix content, a short peptide with host guest-bridge had 40% helix. This helix content hardly changed after the host-guest-bridge was removed. Host guest-bridge acts as an initiator for helix folding in the short peptide.