Clay Langmuir-Blodgett (LB) films play the role of a template in the formation of lysozyme thin layers. Chemisorption of biological molecules onto the anionic montmorillonite surface is confirmed by comparing the IR spectra of organoclay multilayers and the chemisorbed lysozyme. The difference between the height of the monolayers for the organo-modified aluminosilicates and that for their adsorbed lysozyme is about 9 nm. This value is almost twice the length of the lysozyme along the long axis.