In the extrusion process, rapidly tracking the set point of quality factor and eliminating its variation to reduce the off-specification product is important. In this study, the fuzzy gain-scheduled proportional-integral-derivative (PID) controller is used to control the melt viscosity during extrusion processing. A second-order model related to the viscosity and the extruder screw speed is developed empirically to approximate the extrusion system. It is concluded that, in comparison to the well-known Zeigler-Nichols PID tuning control scheme, the performances of the proposed control strategy is preferable both in simulation and implementation.