Blistering is a serious problem for a polymeric lining system because is causes delamination, breakage of the lining layer, etc., leading to a reduction/loss of the corrosion protection. The prediction of blistering is a challenging task and is of great significance in practice. In this paper, a model established for the prediction of blistering on a polymer-steel lining system is presented. The model is based on the concept that a blister occurs if its blistering energy exceeds the adhesion energy of the lined polymer. Several lining systems (polyethylene-steel and fluoropolymer-steel) were selected for evaluation of the model. Experimental data showed that the model can be applied to predict the osmotic blistering when a polymeric lining system works under an aqueous environment.