Through differential scanning calorimetry, isothermal crystallization from the melt of polytetrafluoroethylene (PTFE) has been investigated. PTFE was regarded as one of the polymers for which crystallization is so rapid that the samples crystallize during the cooling from the melt to the selected crystallization temperature. By contrast, we now report that a stochastic behavior is observed for isothermal melt-crystallization of PTFE. In fact, on cooling very quickly the samples from the molten state to the selected crystallization temperature, crystallization during the cooling is randomly observed. Therefore, repeating the experiments until crystallization on cooling was absent, it was possible to investigate isothermal melt-crystallization of PTFE. However, crystallization is very fast; in fact, crystallization kinetics can be followed just for very low undercoolings, while as the undercooling becomes as large as about 15 degrees C, only secondary crystallization is observed. In both cases, the data have been examined through the well-known Avrami analysis, taking into account the different physical meaning of the obtained parameters. For the first cases (actual crystallization kinetics) very low, noninteger Avrami exponents have been obtained. They have been related to the fractal dimension of the crystallites and their values to the morphological observations on PTFE. For the second cases, the typical low values of Avrami exponents of secondary crystallization are obtained. Moreover, isothermal melt-crystallization of random fluorinated copolymers of tetrafluoroethylene with either hexafluoropropylene or perfluoromethylvinylether as comonomers has been studied and compared with that of PTFE.