The performance of La0.75Sr0.25Cr0.9M0.1O3 (M = Mn, Fe, Co, and Ni) perovskitic materials as anodes was studied for a CO-fueled solid oxide fuel cell. The electrocatalytic performance and the tolerance to carbon deposition were investigated, while electrochemical characterization was carried out via AC impedance spectroscopy and cyclic voltammetry. The La0.75Sr0.25Cr0.9Fe0.1O3 perovskite showed the best anode performance at temperatures above 900 A degrees C; while at temperatures below 900 A degrees C, the best performance was achieved with the La0.75Sr0.25Cr0.9Co0.1O3 material. AC impedance spectroscopy was used for a semi-quantitative analysis of the LSC-M-0.1 anodes performance in view of total cell and charge transfer resistance. All anode materials exhibit high electronic conductivity and presumably do not substantially contribute to the overall cell resistance and concomitant ohmic losses.